Tuesday, November 13, 2007

Rheumatology Research News

The American College of Rheumatology recently held their annual scientific meeting. All of the abstracts from research are available online.

Lots of articles have been in the press recently with short snippets of information from the meeting. Notably, several new biologic drugs are showing promise in clinical trials, including two that have been specifically targeted at Psoriatic arthritis: Golimumab and Ustekinumab. The former is another TNF-alpha inhibitor (like Remicade, Enbrel and Humira). The latter is the first interleukin 12/23 inhibitor to show promise in the treatment of Psoriatic Arthritis.

Golimumab has also been in trials for Ankylosing Spondylitis.

It's nice to see the less common rheumatic diseases being targeted in clinical trials as opposed to getting drugs that worked for rheumatoid arthritis applied as afterthoughts.

109 comments:

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Harriet said...

My daughter has got Systemic Juvenile Chronic Polyarticular Arthritis and she is very sick. She is spending most of her time in a wheelchair today.

She has had Enbrel, Remicaide and now she has had Kineret. All of them has lost the effect after a year and a halfish all of them.

In what way is this new drug different from the others?

Hav not lost hope yet!
//H

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Harriet,
"In what way is this new drug different from the others?"

It's a slightly different approach to TNF-alpha inhibition (like Enbrel, Humira, Remicade), but the underlying action (TNF-a) would be the same. More options are good. I didn't respond to Enbrel, but I did respond to Remicade. It's something about the way the drugs are formulated differently that makes them different.

Juvenile arthritis seems to be a different beast as far as medication approvals through the FDA and its international equivalents. You may want to investigate some of the newer drugs like Rituxan and Orencia. I've not seen anything about these two and juvenile arthritis, but it's worth looking into. Those drugs do not target TNF-alpha (and thus might have a better shot at working successfully). I'm not as well-versed in those drugs since they are not FDA approved for the type of arthritis I have (so getting insurance to pay for it would be nearly impossible) and I'm currently reasonably controlled on Remicade. If I recall correctly, Rituxan and Orencia target Interleukin-2, another substance in the body that has been linked to causing rheumatic diseases.

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